I have been on it probably 6 weeks now, my joints all hurt - that is a side effect from Eliquis. It is my neck, upper back, shoulders, upper arms, legs. I am on it because of total knee replacement and after surgery I got a blood clot so they put me on it to dissolve the clot. I do not like it and need a doctor to prescribe something else and have no idea right now if the blood clot is still there. My leg is still swollen along with my foot.