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Anyone have testosterone replacement therapy (TRT) after ADT?
Prostate Cancer | Last Active: 8 hours ago | Replies (64)Comment receiving replies
By March 31st, 2026, it would be 12 months since I stopped Orgovyx and RT. My total Testosterone is 65 now and it was 87 few weeks ago.My oncologist recommends TRT. But I am reluctant because of the cancer recurrence. He says the risk is same if my T goes up naturally or with TRT, based on new studies.My main issues are occasional fatigue bouts lasts few seconds and prolonged exercise tolerance and changes in biomarkers.Any of you have undergone TRT after ADT? What is your experience/What happened when you stopped TRT. Did your T levels go down?
Replies to "By March 31st, 2026, it would be 12 months since I stopped Orgovyx and RT. My..."
Yes I was. That’s how I caught it early. Quarterly PSA testing.
Comparatively, I felt great on TRT. My testosterone level has dropped to 18 since stopping. Below 50 is castration level, the goal of ADT.
Anyone here were Gleason 9 and high Decipher are on TRT after Radiation and ADT ? Did you improve energy levels? Any side effects from TRT. Also please state your age if you don't mind!
I started TRT at 57 years old three months before being diagnosed with PC Gleason (3+4=7) favorable intermediate. TRT Changed my life. The biggest benefit was mental health, anxiety went away, I felt calmer and could think clearer. I was able to put on muscle and weigh is easier to manage. When diagnosed with PC I thought for sure I would be taken off TRT but to my surprise, in all my 5 consultations, all Dr’s agreed I could stay on it. That’s Mayo, UCLA, CA Proton, my urologist and local Oncologist. It helped me tremendously. Of course everyone is different and each our journeys have different twists and turns. It is something to look into though…
This resource may be worth your consideration. It's not a majority opinion or practice yet but offers hope. https://youtu.be/OY9stl6G2nU
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See article attached. As soon as I complete radiation, I will be back on TRT. There are numerous health risks of extremely low testosterone that in my non-medical opinion, far outweigh the risk of dying from prostate cancer that has been treated. See also the Protect T trials comparison of RP, radiation and doing nothing. You will be surprised by the findings. I'm a Gleason 4+3 and 3+4. If my decipher weren't .84 I would do nothing.
Testo Replacement and PCa Article 4-29-25 (Testo-Replacement-and-PCa-Article-4-29-25.pdf)