@lehall125
You and others might find my experience informative. I was diagnosed with essential thrombocythemia about 10 years ago (JAC 2). Hydroxyurea worked well for me for about 8.5 years, until suddenly a painful ulcer appeared on my ankle. For six months, it would not heal, despite much testing, visits with specialists and treatment at a wound care center. After eight months, I stopped the hydroxyurea, at which point it immediately began to heal.

Four months ago, I began with Besrimi (bi-monthly injections., 150mcg). I have had no side effects and with with minimal dosage have been able to reduce my platelets to about 300.