@bbj2009 There is an article on Phoenix Rising called, "The reason why antivirals like Valtrex and Valcyte take such a long time to work in ME/CFS (or don't work at all), according to Dr Martin Lerner."

I caught mine early as my EBNA was climbing up to 600 and was able to see it start dropping. I attached a chart of my data. If your EBNA is over 600 then it's difficult to know if your having any improvement.

One thing I can tell you is even though my numbers where improving I found it more difficult to walk long distance. I kept making myself walk around the block. Before it got better I could hardly walk to the end of the driveway without being out of breath. I was really scared and even had my heart check but everything was ok. One day I started feeling better. It was like a switch flipped. I describe the whole situation to when I was younger and you had to exercise a lot and you get that pain in your side but if you push past that you feel fine.

Anyway, the only number that I can see that shows your on the right track is the EBNA, in my case. Maybe I was lucky to start early...I don't know. Remember, it was not a cure in my case. I still take 1 to 2 grams of valacyclovir every day to maintain but I'm fine.