My TRIMIX experience

Posted by maverick75 @maverick75, Jan 4, 2025

I've been using Trimix for about six months with outstanding results. It did take some experimentation to figure out the best way to make it work for me. With hopes that it may help others, here's what I discovered using this medication: (BTW, I'm 71, one year post SBRT and 4 months Orgovyx)
- I have had to use the oral antidote several times (works well) in the early dose experimentation days for super hard erections lasting more than three hours (4tablets of 30 mg pseudoephedrine. Don't make the mistake of buying the extended release pseudoephedrine tabs). Make sure you have this on hand before you start this medication!
- I had to find the sweet spot for the injection site and depth. For me turns out to be the 10 and 2 o'clock position with the 1/2" needle almost fully inserted around mid-shaft.
- Shelf life on the Trimix in the refrigerator is limited. I can definitely see a difference in the results at the 3-4 week period. For me, it became pretty useless after 4 weeks, even at a higher dose. To help extend the life, I now fill all syringes with the needed dose as soon as I get the medication and immediately place all syringes into the freezer until needed. Now, I take a syringe out about 30 min before needed and it's ready to go. This is working well and my pharmacist said this should extend the shelf-life to 6 months or more.
- After injecting, massage the entire penis and base to help distribute the medication throughout the muscle structure. This will help significantly.
- Stand for the first 5-10 minutes after injection as gravity aids in the blood flow into the penis.
This medication has been a lifesaver for me. I was afraid I'd never see a useful erection again. Now, I'm back to 18 in that regard-- actually better than 18 as my erection stays hard even after an orgasm! Best of luck guys! Be aware that your partner may hide your medication if you use it to often. (-:

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

sahallock1947 | @sahallock1947 | Dec 31, 2025

In reply to @rlpostrp ""OMG"...I can't even imagine inserting needle into my penis...even if it is a 24 or 26..." + (show)

@rlpostrp The view is worth the climb!

pdibello | @pdibello | Jan 3 4:53pm

If I use the "freezing injections" mode, and take out the syringe 30-60 minutes before activity, do I defrost it in the refrigerator or on the counter?

jimb1950 | @jimb1950 | Jan 4 8:27am

In reply to @pdibello "If I use the "freezing injections" mode, and take out the syringe 30-60 minutes before activity,..." + (show)

@pdibello i run mine under warm water.

guyrm | @guyrm | Mar 2 1:50pm

I had RP surgery in August 2019 at 58 yo and got no guidance as to how to recover (and no decent erections since). So, it has been a long time without any real action. I got a pump last year, which gets blood to where it needs to go, but wouldn't last after taking the pump off. Went in last week to get trained on injection. The needle took a second to get over, but they do not hurt. Get an almost usable erection with .o5 and the Nurse Practitioner watching. Got the Trimix Friday and tried .07 on Saturday with decent response - I think it was probably firm enough for intercourse. I am going to try .10 next. The NP did not tell me the Trimix was freezable! I am working on my game plan...

alonrev1 | @alonrev1 | Mar 6 1:19am

In reply to @retireditguy "I'm 71 as well so I'm pretty interested in your experience. What dose did you start..." + (show)

@retireditguy dosage started at 40 U with the weakest available Trimix

rkenitz | @rkenitz | Mar 6 11:36am

In reply to @alonrev1 "@retireditguy dosage started at 40 U with the weakest available Trimix" + (show)

I had rarp surgery in May 2025 and have been taking 5 mg cialis and daily a vacuum pump for penile rehab . Tried Trimix and had very painful reaction so switched to Bimix with good results. Started Bimix dosage of papaverine @ 30mg and phentolamine @ .5mg. At this dosage needed 45 units for usable erection. Urologist recommended changing dosage increasing the phentolamine to 1.5 mg. This increased dosage allowed me to get a usable erection with 15 units. Also, living in Tn had two pharmacy selections. Tried the pharmacy in Nashville and cost was $189 for one vile. Next refill ordered from pharmacy in Chattanooga and cost was $139 for 2 viles plus shipping! So good to work with urologist for best formula mix to minimize the number of units required and different pharmacy to get best price.

alonrev1 | @alonrev1 | Mar 6 12:24pm

I'm I'm 30 miles north of Atlanta in the country in Georgia. I buy mine from mail order in Atlanta. $159 I get 6 viles the syringes and the alcohol prep. No shipping charges and I get it overnight

jeff Marchi | @jeffmarc | Mar 6 12:24pm

@rkenitz

Here are some really good information on making your bimix last as long as possible.
https://connect.mayoclinic.org/discussion/my-trimix-experience/

rkenitz | @rkenitz | Mar 7 10:19am

In reply to @alonrev1 "I'm I'm 30 miles north of Atlanta in the country in Georgia. I buy mine from..." + (show)

@alonrev1 can you share info on the pharmacy you use? Thanks

alonrev1 | @alonrev1 | Mar 7 10:54am

integrity compounding https://mixwithintegrity.com/

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