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jlam1950 avatar

Why not hormone replacement therapy for elderly patients?

Menopause | Last Active: Apr 22 12:01pm | Replies (19)

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Profile picture for laura1970 @laura1970

With your history of TIAs, hormones seem very risky, regardless of your age. Have u tried other, nonhorminal medications?

Fezolinetant, an med designed for hot flashes, is the most effective nonhormonal medicine in population studies to stop hot flashes and increase sleep. Studies of populations doesn’t mean it’s necessarily the correct medication for any specific individual. You may need to experiment with your doctor and try a variety of meds, either alone or in combination, but I can tell you that in my practice I never had a patient with your story whose symptoms I couldn’t improve. In most I could resolve the symptoms entirely.

Gabapentin reduces flashes by half generally. It is also sedating and aids sleep. Sometimes it can be combined with doxepin, another sleeping aid, at low doses.

SSRIs/SNRIs (antidepressants ) like venlafaxine or paroxetine offer relief, though milder than hormones.

If a patient was only partially controlled, sometimes I would add clonidine, though this is a blood pressure lowering medication so if your BP runs in the low side, I would avoid it.

This is all to say thee are many alternatives to hormones. They might not work quite as easily as hormones. But they do work.

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Replies to "With your history of TIAs, hormones seem very risky, regardless of your age. Have u tried..."

@laura1970
1. Risky how?
2. What is your field, that you have patients?
3. I had great experience 11 years on loestrin and would rather stay with a tried and true drug then play with unknowns.

@laura1970 Gabapentin has some very undesirable side effects. It is linked to decreased bone density -- already a problem in menopause -- and to unsteady gait. It also causes brain fog. I was prescribed gabapentin for nerve pain and was told for a number of years that it was safe to take indefinitely. It was only after I tapered off of it that my gait improved significantly -- tripping and falling stopped almost altogether -- and my bone density numbers began to improve. Tapering off gabapentin is a serious issue as well. Any drug that you have to sign for at the pharmacy, as if it were a controlled substance, ought to be very carefully weighed against whatever benefit you would hope to get.