Darolutamide Monotherapy

I hope they can find and zap the metastasis that are causing your PSA rise.

I suppose you got a PSMA pet scan. How many metastasis did it find? Some doctors feel that just zapping those is all you need to do. Hopefully that works for you.

Hey Jeff, PSMA Pet Scan, showed 5 mets-spots that need Zapping. Hope, agreed, hope at this phase comes naturally.

The maximum they like to zap is five Metz, so you are in a perfect spot. Hopefully, they can zap all those turkeys and your PSA will drop significantly. Let us know what’s happening.

I know someone who had many more than five zapped. He went back a few times and did pretty good as a result

Wondering if anybody would have experiance deleting elligard going mono nubeqa. How long before elligard simptoms wore off. I was diagnosed and put on degrelex monthly inj in december2024. Six months later had hypofractionated radiation 6 doses once week psa then 0.1 3 months later psa rose to 2.6 started elligard and nubeqa and in 3 month psa 0.1 had 2 scans ct with iodine and nuclear bone scan zero cancer found so have dropped elligaurd goind mono nubeqa on my own without oncologist. Thanks

@safaritours
A lot of people over at the ancan.org Weekly advanced prostate cancer meetings have gone to Nubeqa Without ADT. It works quite well for most people. I even stopped Orgovyx for eight months while on Nubeqa And was undetectable for that time.

You’ve been on ADT for about a year. It could take nine months to a year before your PSA comes back to normal. It varies a lot, depending on age and just how your body recovers from the ADT. No one can tell you how long it will take. In the eight months, I was off ADT my PSA rose to 50, it was rising 25% a month.

@jeffmarc

Hey Jeff, what are you waiting for to go mono Darolutamide? I know you're in a very good group that studies this. Just curious. I'm on ADT right now. Just got my last 6 month Eligard shot 2 months ago so this might be something I'd be tackling in the future.

Doug

@dpayton
My case is different from others. Because of the BRCA2, I need to keep as much protection as possible, and that includes Orgovyx, even though I became castrate resistant six years ago, Which meant that ADT wasn’t really fully effective anymore.

I did stop orygovyx for eight months, with my oncologist’s approval, because we both figured my testosterone would never come back, since I’ve been on ADT for almost 8 years. My testosterone came back Quite fast, When it hit 50 at just over seven months, my oncologist said the stampede trial evidence showed that I should go back on ADT. While Zytiga did keep my PSA low, It varied between .2 and .7 for the 2 1/2 years I was on it. I was undetectable for one month. Most people on that combo are undetectable the whole time. When I stopped it, they found a metastasis on my spine. It had to be zapped. Zytiga didn’t prevent that from growing.

When I was on Zytiga For two years, I started taking three pills instead of four for 19 days, because I wanted to see if it would help with the brain fog. In those 19 days, my PSA went from .2 to 1. That showed that my BRCA2 was quite aggressive if I cut back even slightly on the drugs.

So as a result, I’m sort of stuck using ADT and Nubeqa.

@jeffmarc can likely clarify, but it's my understanding that Nubeqa allows testosterone to rise but its purpose is to prevent cells' receptors from using it, which means not just cancer cells but all cells. Quality of life may not be much different than on ADT, but Jeff and others have indicated that it has fewer side effects and it is less likely than some to create "brain fog" and affect heart issues. I look forward to others' responses.

@jeffmarc I’m assuming you’re talking testosterones numbers not PSA?

I received my last Leuprolide shot one year ago this month then went off it to do the Nubeqa mono Therapy with the support of one oncologist, but not the other. It was a three month shot for a total of 22 months on it this time. Just now showing some minor recovery on my testosterone level at 54,PSA remains undetectable. Scans have been OK but a little indecisive. I will get another scan next month. I will add that I have had a total of 64 months of Leuprolide intermittently over the last 11 years. I’ve had surgery, salvage Radiation twice,spot Radiation once, carboplatin,Docetaxel, and Pluvicto. People that don’t know it can’t even tell that I have stage four Prostate Cancer.