@dpayton
My case is different from others. Because of the BRCA2, I need to keep as much protection as possible, and that includes Orgovyx, even though I became castrate resistant six years ago, Which meant that ADT wasn’t really fully effective anymore.

I did stop orygovyx for eight months, with my oncologist’s approval, because we both figured my testosterone would never come back, since I’ve been on ADT for almost 8 years. My testosterone came back Quite fast, When it hit 50 at just over seven months, my oncologist said the stampede trial evidence showed that I should go back on ADT. While Zytiga did keep my PSA low, It varied between .2 and .7 for the 2 1/2 years I was on it. I was undetectable for one month. Most people on that combo are undetectable the whole time. When I stopped it, they found a metastasis on my spine. It had to be zapped. Zytiga didn’t prevent that from growing.

When I was on Zytiga For two years, I started taking three pills instead of four for 19 days, because I wanted to see if it would help with the brain fog. In those 19 days, my PSA went from .2 to 1. That showed that my BRCA2 was quite aggressive if I cut back even slightly on the drugs.

So as a result, I’m sort of stuck using ADT and Nubeqa.