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Walking pneumonia led to lung nodule to lung mass! 2 biopsy this week
Lung Health | Last Active: Dec 28, 2025 | Replies (32)Comment receiving replies
@lls8000 I was going to start Keytruda Xmas eve, but when I went in, the doctor showed me new information about a biomarker that I had and it just came in. Now, there's a new plan. He showed me an article he printed out from NEJM about stage IV lung cancer with metastases to the brain and the statistics were somewhat encouraging. So, I'm starting on cisplastin, Pemetrexed, both chemo and Tagrisso (targeted). I have an EGFR mutation- thr Exon 19 deletion and PD-L1 22C3 of 80% , being over 50% is good. So, I'm hoping for the best but dreading the side effects especially vomiting. I haven't thrown up since I was 12 years old and I'm 67!!! So this is the plan beginning Jan. 2. I have a lot of head pain where there is cancer on the skull and brain. I have a radiologist consult to see if it can help with my pain. I don't know if it can fit in with the other plan or not.
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@medtech4, I'm glad that your tests came back quicker than expected, and that they identified a targetable mutation. The targeted therapies can be a game changer where treatments are concerned. I see that they are starting you on chemo too. Of course, make sure the team is proactive with the anti-nausea meds. They should help! I wonder if the Tagrisso may help with the head pain. Did your doctor give you an idea of how long it would take to notice results from the meds and chemo? When I started my targeted therapy, for ALK not EGFR, I could tell it was working in the first week because I started feeling better and could breathe easier.
There are others with EGFR exon19 deletion in the lung cancer group too. You'll see some of their comments in these discussions too. @flusshund, Matthew is a long-term EGFR survivor.
Here are couple of links to discussions that may be helpful.
https://connect.mayoclinic.org/discussion/tagrisso-for-lung-cancer/
https://connect.mayoclinic.org/discussion/carboplatin-plus-permetrexed/