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How long have you been on Orgovyx (relugolix)?
Prostate Cancer | Last Active: Jan 9 12:02pm | Replies (44)Comment receiving replies
@brianjarvis Not all the drugs you mentioned work the same way. In the case of Nubeqa, it acts in concert with Orgovyx . Nubeqa is an androgen receptor inhibitor that works by blocking any remaining male hormones, including the small amounts of testosterone still present in the body from binding to the prostate cancer cells.
Question: Are any doctors recommending drug holidays after 6-12 months when the PSA level goes to near zero? Mine insists I remain on Orgovyx + Nubeqa for two years.
Replies to "@brianjarvis Not all the drugs you mentioned work the same way. In the case of Nubeqa,..."
@lsk1000 said, "Mine insists I remain on Orgovyx + Nubeqa for two years."
Yes, that's my friend's situation, PSA near zero, simple soft tissue location zapped with radiation and no metastasis seen, serious side effects from Orgovyx, but his oncologist recommended 18 months at the start and it's only been a year.
There are always concerns and "playing it safe" might be to stay on the ADT continuously, then again we want to see actual numbers, if the extra "safety" is on the order of 1% and the side effects are becoming overwhelming, you don't want the theoretical safety to keep you miserable when the odds are that you'll be fine with a break. And the perceived side effects suggest that real damage is being done so "safe" starts to lose its meaning.
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@lsk1000 That’s correct; each of the 2nd generation androgen receptor pathway inhibitor therapies is different from each other and developed as (hopefully) an improvement over the previous one(s): see attached graphics.
Some doctors do intermittent ADT; I’ve never looked into it.