I just wanted to share that after taking l letrozole for 6 months I started feeling like I was always having UTIs. I spoke with two gynecologist, who both said that because letrozole depletes all estrogen in your body, the vaginal wall gets extremely thin, and your bladder can be irritated. Both recommended taking bona fide reverie. You can purchase it online or I understand Walmart sometimes carries it. The gynecologist can give you a code for discount subscription and a sample if you want to try it. After taking it for a month, my constant urinary tract symptoms completely disappeared. It is a natural substance used in your vagina and it helps to thicken the vaginal walls. Anyway, just wanted to pass it on for those of you taking letrozole and having similar symptoms.