@colleenyoung I do have a daily routine of a 30-minute nebulizer treatment in the morning when I first get up (first with albuterol and then with 3% sodium chloride), and then the same treatment around 4:30PM every afternoon. I used to use a vibrating vest with every treatment, but I have a pacemaker, and the vest's vibrations made my pacemaker think I was running somewhere at full speed and was painfully hitting the maximum heart rate limit for the pacemaker! 🙂 So I gave up the vest, and my wife used a Theragun on my back periodically to break up stuff in my lungs. For the past couple of years, however, I haven't needed my wife to "beat up" on me! The Trikafta has really helped my lungs. Despite all the treatments, I have had a few lung infections over the years -- a few of which required hospitalization -- and have required various drugs (IV, etc.) to address the infections, directed by both my CF doctor at Mayo and an infectious disease doctor.