@phxbarb, like you I take generic Amitiza (Lubiprostone). I hope your restarting it, or perhaps Ibsrela improves your IBS-C

Amitiza is actually the latest thing incorporated into my constipation treatment. A consistent diet full of specific foods that help is important for me, and I start feeling my GI working exactly 26 minutes after hopping on an elypitcal machine every morning. Then, pelvic floor therapy that made absolutely no sense to me at the beginning has been a game-changer. I added consistent daily MiraLAX and senna before ultimately starting Amitiza. It all becomes so exhausting at times to maintain a schedule for all these things but then I remind myself of how “regular” I feel now in comparison. It certainly did not get better overnight, and I absolutely do not want to go backwards. It certainly has not been an “easy button” but I consider it a win!

I do know Amitiza is a prescription drug. Do you get help from the doctor that prescribes it for you? What is your diet and physical activity look like, do you think you may have room to improve how your body functions in a way that would sorta help your body….help the medicine you take work better? (I hope that makes sense)