I am not having any negative side effects so I am just working with managing my symptoms at this point! I have a spiked issue with my spine issues that just popped up - as those of us with chronic issues know how that works. So all hands on deck right now with PT, heat, Tylenol etc in addition to the lyrica. It isn't a cure all but it keeps the underlying base pain from a 6 to a 3. But I still have to work around this additional issue a bit. If that makes any sense.