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DiscussionAnyone have severe bone (spine) loss with recurrence of PC?
Prostate Cancer | Last Active: Dec 19, 2025 | Replies (8)Comment receiving replies
Replies to "I'm off Lupron since Jan 2023. (Side note, some hot flashes continue so there's probably some..."
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@grandpun
It is impossible for Lupron to be in you for that long. It’s half life is only a few hours. When you get the shot, it’s one month three months four months or six months. The drug does dissolve after that amount of time and disappears since the half life is so short.
What can be going on is your testosterone is not increasing. I have not seen you mention your testosterone level? After getting Six months of Lupron, my brother was still having mild hot flashes when he was off it for one year. His testosterone still was below 150.
If you are still having fracturing in your spine, getting one of those bone strengthening drugs, I mentioned could stop this from happening.