Can Neuropathy be cured?

This is just my take. Will it be cured. Yes. At a date TBD. First breakthrough will be pain management treatment mitigating pain. Then stopping the spread. Finally reversing PN. But hey, I'm 76 yo and I was told as a 30 year old by an ENT specialist that I would not live to see damaged left auditory nerve being repaired. Like my PN, I've learned to thank medical science for amazing advances that have got me this far and then live with the rest. And thanks also to forums like this!

@jamessaxo May I ask, how many mcg of B12 do you take? I recently bought the Nature Made B-12, Extra Strength 2500 mcg. Wondering if that's too much.

I looked up side effects. U can too. Go to local library and use their
internet.

@thomasmichael I'm 66 years old and have zero illusions about seeing a cure for this f@cked up disease in my lifetime. I'll be amazed if I live another 10 years at the rate that I'm falling apart, both mentally and physically.

Sorry to hear that. Better luck in the next life.

@rollingf thanks rolling for your sugar comment.
Add : low B12. A function of how much animal protein eaten.

I'm 58. I am a diabetic since 2017 and peripheral neuropathy started with my feet (tingling, numb, painful nerve discomfort, etc..). Until this day(2025), I have been dealing with incurable, unmanageable, uncontrollable diabetes II and painful body peripheral neuropathy from feet, legs, waist and hands starting to become more and more numb especially feet as I have to wear two soft socks. And fell 5 times as legs went dead as no longer functioned properly. This was the most terrifying and scary feeling as I thought became suddenly paralyzed.

After all the doctors, neurologist, emergency rooms, hospitals, etc.. , plus prescribed medications (PR gabapentin/gabapentin, Juniva, Metformin, Duloxetine, etc.. and even purchased massagers, creams, and stuff to help with PN at no avail....Sorry to say, I completely regret to spend thousands and thousands of dollars (Out of Pocket and/or Insurance) for PN and not to mention, disability claims have been denied twice and must endure the pain without telling anyone even with employers.

After 8 years with such painful conditions, you DO NOT want the neuropathy (PN-nerve damage) to grow, spread and affect your entire feet, calves, thighs, waist and hands as it is an extremely terrible feeling along with an uneasy painful and frustrating state of mind, major anxiety, stress, sleepless nights, nervousness with daily activities, etc.. And not to mention, impotent for the last 7 years and specialized doctor(s) want 20K to make you believe that they can help with it. I declined!

Sadly, advise for these serious mental and health complications and conditions were experienced as "NO CURE" ! The final solution mentioned by Neurologist was to amputate feet, and legs, and maybe hands. I could not live with myself with such a decision. I will continue to endure and suffer which I have accepted to convince my mind this nasty discomfort is strictly a part of my remaining style way of my life and golden years.

As I feel discomfort and pain, I purchased a 3 year dog (German Shepherd) to help encourage, smile, and walk at least 4 times a week which helps body, muscles, and seldomly nerves but still painful. He is amazing! I seriously regret not adopting a dog many years ago...

I found NO devices, creams, massagers, meds, specialist, doctors, etc. to ultimately eliminate nor majorly reduce the discomfort and sleepless nights of Peripheral Neuropathy not to mention diabetes II(except for short/long term insulin to lower blood sugars on a daily basis - constantly ). Again, I molded and learned to ignore both awful symptoms as it has been a part of my remaining life. An extremely sad way to live into your golden years.....

My advice is to eat healthy, "exercise', possibly adopt a pet for serious encouragement, and most definitely "Save your Money"…! As far as diabetes, I take insulin each day and eat healthy to help maintain blood sugars and when very low or high, PN brings out more of the dreadful and nasty pain in feet, legs and waist plus hands. And ultimately alters and brings extremely sad moments in my mind in which I try to fall asleep with sleepy pills and when at work must excuse myself some way to regain some control.........

My very temporary relief is 'icy hot' cream rubbed around feet, legs, hips, and hands which becomes expensive $15-25 week or two. With lengthy research, studies, doctors, specialist, I am still with the discomfort and pain as I found 'no cure.' We can place a person on the moon but can not find a cure for PN which I sometimes feel my life is pretty much over as I no longer have any faith in our medical field and/or funding to find a real cure.

i do not mean to scare anyone but this is simply my long dreadful experience with PN plus diabetes.

My prayers are with all of you …

Since testing positive for gluten intolerance and eliminating all gluten (wheat, barley,rye) my neuropathy is almost all gone. Also, my breathing has improved. and I gained back some weight that I had lost. My neurologist gave me the blood test which showed that I had this autoimmune condition. I also take some supplements including ALA, eat lean proteins, lots of fruits and veggies and do some gentle exercises. I am working on getting more sleep and trying to keep stress to a minimum (not easy).

I now believe that if we can tackle the cause of our PN we can then take better control of it.

@michhino
As of January 2026 it will be 10 years since I was diagnosed with idiopathic SFN. I spent one week at the Mayo Clinic in Rochester back in June of 2021 hoping they might find a cause, they didn’t. I retired from a major pharmaceutical company and know how to research and interpret clinical trial data. I have had 2 trials of a Spinal Cord Stimulators which failed. I have taken every drug out there and every test multiple times. The only neuropathy drugs I take are pregabalin, duloxetine and Low Dose Naltrexone 4.5mg. The drug I had high hopes for was an injection called Engensis from a South Korean company called Helixmith. I have tried for several years to get an update on the drug but the company went dark. YESTERDAY, I finally received a reply from someone that used to work for the company here in the United States, and he told me they had 2 Phase III trials that did not meet the primary endpoint. They also a a money issue in continuing the research. Basically the drug is very much DEAD.
There is nothing out there that will “cure” idiopathic SFN. IF they can identify a cause, then hopefully treating the cause will cure the neuropathy. I have never heard. Of someone actually curing neuropathy. The only drugs in trial now that I know of address the pain only (palliative) and none come anywhere close to a cure. For pain, the first non-opioid pain killer invented is a drug call Journavx. It has a very unique mode of action, and can be effective in pain relief for some patients. Other drugs with a similar MOA are in research as well.
My industry has done an amazingly poor job in their approach to neuropathy. They will develop tons of me-too drugs but have failed miserably at dealing with the degeneration of nerves and reversing it.
I am not offering any medical advice, but be careful what snake oil salesmen are selling. Desperate people sometimes lose their ability to reason logically when looking for help. I will advise anyone with neuropathy to exercise AS MUCH AS POSSIBLE with aerobic and resistance training if you can. I truly believe it has he with my discomfort. Good luck to all of us.

@arcuri24
Thank you for your extremely interesting message about PN.
Can you tell me what the the blood test is that your neurologist ordered?
Thanks you so much.