I have been on Besremi for almost a year now. Started me off on 100mcg the first 2 weeks and my moods got a little whacky. I was irritated more than usual, getting short with people. I also had some nausea and worsening fatigue. I was dropped down to 50mcg for about a month while also adding a different anxiety medication and nausea pills. They gradually upped my dosage from there. I have been sitting on 300mcg for a while now. At one point I was taken off of the Besremi because my eyes did a funky thing, but all was good after all tests were complete. I tend to inch in the injection site, but I also don't use the same injection site each time. I rotate them. I still get nausea from the Besremi and I have hair loss. I have very bad dry skin, and very bad dry mouth. Also, the taste of foods and drinks have altered. I too also have what they call brain fog. I still have what I call my flare ups but nothing like it used to be. Other than these issues, Besremi has been my life saver.