Dental Cavities on Prednisone

Posted by crs1950 @crs1950, Dec 11, 2025

My husband was diagnosed with PMR 1.5 years ago. His rheumatologist has him on 7 mg prednisone daily plus 8 mg methotrexate one day a week. He started on 30 mg prednisone. The past three dental exams have found six or seven cavities that needed fillings. We were not informed about this possible side effect when starting prednisone. The dental bills are insane! Has anyone been able to convince their medical insurance to cover this? It’s not caused by bad dental hygiene. It’s a result of the prednisone to fight the PMR.

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Profile picture for jfannarbor @jfannarbor

As a dentist, I do not know of any relationship between prednisone and tooth decay. Tooth decay has been well researched. The three absolute requirements are: 1 refined carbohydrate, 2 streptococcus mutans and, 3 tooth structure. Without any one of the 3 above items there cannot be tooth decay. I do not know of any relationship between the above three and prednisone. Without knowing your personal situation my first guess is you are going to a new dentist. My experience is if you go to a new dentist that does not know your caries rate and they will try to fix every minor defect. Caries in most people can be completely controlled with good oral hygiene. Does your dentist or hygienist review you oral hygiene at each visit? If you do not know the quality of your oral hygiene you can not correct any defects. My daughter is 42 and has no cavities or fillings due to her diet and oral hygiene. She obviously has a low caries rate. I have told her if a dentist ever tells her she needs a filling, get a second opinion. Caries free individuals at 42 are not going to get any cavities unless their diet or oral hygiene changes

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@jfannarbor

This study focuses more on dental caries and long term corticosteroid use.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10475248/
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No research ever provides definitive answers to these questions and this one is no exception. This study suggests steroid inhalers are mostly the problem.

"Future randomized controlled clinical studies are warranted to confirm these findings."

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Profile picture for Mike @dadcue

@crs1950

I don't know exactly. I had a Delta Dental plan that covered cleanings and "preventative care" every 6 months. Apparently my plan had a provision for cleanings every 3 months for certain medical conditions. My dentist asked me about my medical conditions but we never discussed the details. I wouldn't have said I had PMR but she knew I was on Prednisone.

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@dadcue - we are covered by Kaiser Permanente’s Medicare medical and dental insurance. I will contact them this week to see if we have that three month provision in our plan. Thank you so much for your replies and suggestions.

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It's possible that the methotrexate, not the prednisone is causing this. Lots of research online.

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Profile picture for Mike @dadcue

@jfannarbor

I would be the first to admit that I don't know anything about it. My dentist didn't know what changed but I had an increase in cavities when I was on Prednisone. My dentist was conservative when it came to fillings so she would commonly put a "watch" on potential problems.

Those things she put a watch on turned into cavities rather quickly. The solution was more frequent visits and cleanings---every 3 months. My dentist got my dental insurance to approve frequent visits because of medical reasons.

I don't think I had "new cavities" very often but frequent revisions of old fillings that "leaked." I got the impression it was the tooth structure around the fillings that was the problem.

In any case, my dentist wondered if Prednisone was causing my problems. My dentist thought prednisone could affect the oral environment, which likely contributed to changes in my mouth's biome and a dry mouth.

What is your take on the following research? I don't know if it is credible or not.
https://juniperpublishers.com/adoh/ADOH.MS.ID.555801.php
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I suspect more research is needed.

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@dadcue I hope that your dentist told you which teeth she was watching so you could pay more attention in cleaning those teeth. I am amazed how many people I come in contact with who see their dentist on a regular bases and every visit there are teeth to fill. Dental caries is a preventable disease as is periodontal disease. Dental caries in not like cancer. Caries can arrest and never progress if your oral hygiene removes all the carbohydrates that feed the bacteria that cause decay. I conducted a randomized clinical study that looked at treating questionable carious lesion and there was no benefit in treating questionable carious lesion prior to those lesion becoming clearly carious. The size of the resultant cavity preparation was not different between early treatment (questionable) and later treatment (unquestionable caries). If you are interested in the articles search PubMed with Author Hamilton JC and any field dentistry.

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Profile picture for Mike @dadcue

@jfannarbor

This study focuses more on dental caries and long term corticosteroid use.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10475248/
------------------------
No research ever provides definitive answers to these questions and this one is no exception. This study suggests steroid inhalers are mostly the problem.

"Future randomized controlled clinical studies are warranted to confirm these findings."

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@dadcue I do not question that no one randomized clinical study will answer any medical question. One of the problems with studying the question, "Is prednisone related to tooth decay" is what is the level of oral hygiene prior to taking prednisone and after taking prednisone due to some disease. Often the disease the requires prednisone causes physical and mental problems and life style changes that affect the level of oral hygiene.

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One of the best tools to give dental patients is disclosing tablets or drops. I tell them
to brush their teeth normally and then use the tablet and wherever there are red spots those are areas they are routinely “ missing”.
Have them do this for a week and they will usually develop a better routine to get to those spots.
Then let them recheck once a week.
You can’t see what you’re missing if you don’t do that.
Good luck,

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Profile picture for jfannarbor @jfannarbor

As a dentist, I do not know of any relationship between prednisone and tooth decay. Tooth decay has been well researched. The three absolute requirements are: 1 refined carbohydrate, 2 streptococcus mutans and, 3 tooth structure. Without any one of the 3 above items there cannot be tooth decay. I do not know of any relationship between the above three and prednisone. Without knowing your personal situation my first guess is you are going to a new dentist. My experience is if you go to a new dentist that does not know your caries rate and they will try to fix every minor defect. Caries in most people can be completely controlled with good oral hygiene. Does your dentist or hygienist review you oral hygiene at each visit? If you do not know the quality of your oral hygiene you can not correct any defects. My daughter is 42 and has no cavities or fillings due to her diet and oral hygiene. She obviously has a low caries rate. I have told her if a dentist ever tells her she needs a filling, get a second opinion. Caries free individuals at 42 are not going to get any cavities unless their diet or oral hygiene changes

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@jfannarbor it is my understanding that prednisone causes xerostomia (dry mouth) which is linked to gum disease and cavities. Am I misinformed?

For medication induced dry mouth, I take biotine. I tolerate it much better than saliva substitutes. What is your recommendation for dry mouth?

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Profile picture for laura1970 @laura1970

@jfannarbor it is my understanding that prednisone causes xerostomia (dry mouth) which is linked to gum disease and cavities. Am I misinformed?

For medication induced dry mouth, I take biotine. I tolerate it much better than saliva substitutes. What is your recommendation for dry mouth?

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@laura1970 Yes, my dentist said I had dry mouth and suggested the tablets that encourage salivation. She had noticed a marked difference in my teeth and jaw by comparing the xrays and was quite alarmed. I don't think she had had a prednisone patient before.

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Profile picture for Mike @dadcue

@jfannarbor

This study focuses more on dental caries and long term corticosteroid use.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10475248/
------------------------
No research ever provides definitive answers to these questions and this one is no exception. This study suggests steroid inhalers are mostly the problem.

"Future randomized controlled clinical studies are warranted to confirm these findings."

Jump to this post

@dadcue great article. Thanks 😊

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Profile picture for laura1970 @laura1970

@jfannarbor it is my understanding that prednisone causes xerostomia (dry mouth) which is linked to gum disease and cavities. Am I misinformed?

For medication induced dry mouth, I take biotine. I tolerate it much better than saliva substitutes. What is your recommendation for dry mouth?

Jump to this post

@laura1970 I have been on and off prednisone due to PMR, mainly on, for 35 years and I am a dentist. I have not had dry mouth or a problem with dental caries. The only study I could find related to dry mouth and corticosteroids was done in rats and used dexamethasone which is much stronger than prednisone. I do not doubt your dry mouth I just wonder about the cause. Prednisone is given for auto immune diseases and some of those diseases cause dry mouth. Again there may be a connection between prednisone and dry mouth and this would be a good forum to learn about it. I personally have not experienced it or know of studies that prove it, but I am all ears.

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