@jeffmarc I would presume a lower dosage is possible, shots or pills.

My guess would be that this is not an unreasonable thing to do but that frequent monitoring and dose adjustment would be required and no provider wants to do that much work.

But it could at least be evaluated in studies.

(heck, start with rats, or whatever they use!)

I see ADT has been used for decades or longer, depending on what you count, and in all that time, no studies?

It might fail, but living with milder side-effects might be a winner at least for some, of course it depends on all the metrics I see people talking about and then actual monitoring and adjustment for each specific case.

My questions are colored by my experiences with other drugs for other conditions where the standard dosing has often turned out to be too high for me or the optional higher dosing has increased side-effects but not been any more effective.