@mmkennedy I would like to talk about headaches associated with ET. Getting the platelets down is important. The headaches are usually caused by microvascular ischemia. That means tiny vessels are not getting the blood they need to bring oxygen to the brain. So, taking baby aspirin makes the platelets more slippery and less sticky so the microvascular blood vessels can deliver blood, oxygen and nutrients to the brain. It is a 2 step process, hydrea (or other therapy) to reduce the number of platelets and aspirin to make the platelets that are there less sticky. People with ET have too many platelets and these platelets are not normal platelets- they behave differently. We need to keep our blood flowing normally to all parts of our body not just our brains. We need the blood to flow to all of the micro vessels such as our eyes, kidneys, bowel area, and lungs. Big clots cause tissue death, little clots can cause pain or decreased function. It is a delicate balancing act we have to perform. Good luck everyone.