@mumblipeg From all of us on Hydroxyurea, this is a common occurrence. I stayed at 850, with dose changes and now steady dose, I’m going up and down between 350-450. I’d hold off and let them play with the meds again being this number isn’t really dangerous currently. Are you getting a Bone marrow biopsy soley because your platelets are creeping up? Do some research. Ask questions. Mainly will your treatment change from the results. Good luck!