I also have severe issues with arava. Instead of changing medications they prescribed Diflucan for 7 days then I have to take it once a week. I not only have RA but I also have progressive systemic sclerosis, Hashimoto, stage 3 kidney disease, COPD, autoimmune asthma, latent TB, and hypertension. With all the medications I have no quality of life and my days revolve around taking medications at the proper times. The medication list is to long to list but I wonder if just throwing the medications out and trying diet and homeopathic means would improve our quality of life.