@pdhuston Hi, after going through 2 years of extreme stress, 3 of my doctors suggested it, saying new research finds it safe, helpful, it could help my overall lack of stamina, low energy, sleep interruption. I did not have a lot of symptoms but I thought wth, I'll give it a try. First 4 months were positive and I "felt like a million bucks." I'm now on a continual search to figure out what's causing many symptoms. Best NON MEDICAL advice I have for you is start low dose just in case. I think I'm an outlier with a very sensitive system, so these intolerances might require I stop HRT. Definitely find a doctor to prescribe this who will LISTEN and be patient and who KNOWS their way around HRT. Good luck!