I had cold/flu symptoms & sinus infection that I couldn't get rid of, the 1st 2 years I was on Prolia. I read a medical paper that said studies showed that Prolia seemed to interfere with our immune system's ability to fight viruses/infections in the 1st 2 years, and after that these problems lessened. It also said to be vigilant during this time re: care. I got the new brand (Jubblio..sp??) for my last shot and my right arm hasn't been the same since. It feels like an injury? I'm going to see a physio today about it.