Hi, my name is Debbie. I have RA, Diabetes 2, Fibro and Osteo, I was on methotrexate and it didn't agree with me. I take melocicam, an anti inflammatory and it works for me. I have to live a spontaneous life as the fatigue that I experience rules my life. If I do anything stenous the next day I am bedridden. I have multiple spurs in both knees and they lock up at night. I get up and literally have to apply my hands to my knees to straighten them out. It hurts like the dickens and is happening just about every night.