I have been on Brinsupri (25 mg) since September 15 after a 2 1/2 year battle with severe bronchiectasis. I am 87 years old, in otherwise excellent health, and have been under the care of Mayo Jacksonville. I have had zero side effects, have regained 10 of the 20 pounds I lost during the previous two years, my energy level has totally come back, am now sleeping a normal 7-8 hours rather than 9-11, my appetitive is improved--in short I am a new man and can't say enough about the drug. I used to have 10-15 violent coughing spasms (exacerbations) per day--I am down to one, maybe two with some mucous production.