@rimord Interesting you ask this question. The thing about the progression from MGUS to Smoldering MM to active MM is we don’t always test to catch all the phases. In my case we missed diagnosing MGUS but…I lost some blood during my cardiac ablation in 2023. About a yest later I finally had labs drawn by my pcp. I was iron deficient. She sent me to hematologist who drew the correct labs and I went to a MM specialist at the closest city cancer center. There I was diagnosed with SMM. I think I had MGUS for a couple of decades based on abnormal labs then but they didn’t do the correct labs to detect it. So I don’t think my cardiac ablation caused my SMM, but I think the subsequent blood loss that made me iron deficient and symptomatic helped to find the SMM. I’ve had a couple iron infusions and feel better. I’m on the watch and wait path which does make me a bit anxious. Next rounds of labs are at the end of the week. Gulp.