Biologics work for only 35-50% of those w/RA...I've tried 5, none worked; Methotrexate doesn't work for me; Plaquenil made me ill (oooh that rhymed!); get relied from only steroids or Naproxyn. The notion of becoming "normal" with these drugs is PR, not reality for many - and at a cost of some nasty side-effects. So, don't despair. Keep searching for what will work for you with the understanding that we have a serious, degenerative disease that can at best be mitigated with today's science, not eliminated.