each RA drug will either work or not work for each individual. Each RA drug does have potential dangerous side effects. the biggest can be lymphoma and you immune system is supressed so much you can get colds, viruses, flu very easily. I have a 75 years old friend who was so dischanted with all the different RA medicines and side effects that she went on medical marijuana after getting her license that she said that she has never fely better. now she can't drive anymore because if you are in an accident and get blood tested and it is discovered that marijuana is in your system that is an automatic DUI. she told me that the medical marijuana makes you feel better but your awareness of pain is known but not felt. i think it suppresses the neuro response of pain back to the brain. thsi is not a cure for RA but enable one to better tolerate the pain. as far as what RA drug to take, i can't tell you.... best wishes and god bless......kozlo52