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Jardiance for congestive heart failure: pros and cons?
Heart Rhythm Conditions | Last Active: Dec 28, 2025 | Replies (39)Comment receiving replies
Thank you to both mikeydc2008 and to marybird. I still have not taken Jardiance. All of your comments are very helpful. My nephrologist has now decided that Jardiance would not be a good option for me because I was on another (less expensive) SGLT-2 inhibitor drug, and my creatinine level increased. She had me discontinue it, and my creatinine level decreased. So, she is no longer recommending a SGLT-2 inhibitor drug, due to my kidney issues. However, I see my cardiologist this week. Since I have HFpEF, he wants me on an SGLT-2. Reading the side effects mentioned here, I may err on the side of caution and not take it. By the way, I asked my primary his opinion, he has a relative who also passed away due to necrotizing fasciitis, described by Marybird. Without another echo, I don't have any idea how bad my diastolic dysfunction is (a few months ago it was diagnosed as Grade 3 Severe. So, I am still in a bit of a quandary - I highly appreciate everyone who has responded with their experiences.
Replies to "Thank you to both mikeydc2008 and to marybird. I still have not taken Jardiance. All of..."
It's a new drug, so no one knows what the long-term consequences are. It initially was for the kind of heart failure with low and lowering ejection fraction and was not recommended for heart failure with PRESERVED ejection fraction (HFpEF). Fairly recently, "they" have decided that those of us who have HFpEF should take it, too, and say that it is helping significantly.
Nonetheless, my cardiologist with 30 years experience will not prescribe it, because she has concerns about the side effects and long-term effects. I think she's right.
Most important, though, is your kidneys, and it seems clearly contraindicated in your case, as your doctor says. Maybe ask what you can do to slow the progression or whether there's any way to reduce the severity?
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@bettycll in your shoes I'd probably not want to take another SGLT-2 drug either, with the evidence you have of the drug adversely affecting your kidney function, so much that your nephrologist took you off the drug. It's hard to imagine your cardiologist wanting you to take a drug that affects your kidney that way, if he/she knew of the effects of the drug on your kidney. You might have that talk with your cardiologist, and see what he/she says.
Are you taking other drugs for your heart failure?