Here is some accurate information from a particular study about what is most probably happening with the information you have provided:
I’m really sorry you’ve been going through all of this — especially after already dealing with a staph infection and years of symptoms that must have been frightening and frustrating. What you described with the B6 toxicity is very real; B6-related nerve irritation can cause many of the symptoms you mentioned (tingling, burning, clumsiness, visual disturbances, tremor, “hot feet,” etc.), and unfortunately it can take months for the excess B6 to clear from the system and for the nerves to calm down.
What’s tricky is that once you stopped the magnesium supplement (which contained the B6), the original issue—nighttime cramps—came right back. Even with “normal” magnesium on blood tests, people can still get cramps because blood levels don’t always reflect what’s happening inside the muscles.
A few things that people with similar experiences have found helpful:
1. Try a magnesium form that contains no B6.
Some tolerate magnesium glycinate or magnesium citrate without any B6 added. Even 100–200 mg before bed can help if your body responds to magnesium.
2. Check ferritin (iron stores)
Not just hemoglobin. Low-normal ferritin can trigger severe nighttime cramps and restless legs–type symptoms.
3. Peripheral nerve irritation from the old B6 toxicity:
Even though your levels are dropping, irritated nerves can cause the muscles to “misfire” at night. That can take 3–12+ months to settle. Some people do physical therapy or gentle nerve-gliding exercises and notice improvement.
4. Try non-drug physical measures that help some people with stubborn cramps:
• Warm foot bath before bed.
• Heating pad to calves/feet.
• Gentle calf and hamstring stretching.
• Massage or foam rolling.
• Wearing loose socks (helps some by reducing nerve irritability).
• Trying a topical magnesium (no B6).
5. Ask the doctor about prescription options for severe nighttime cramps
If it is disrupting sleep every night, some physicians consider:
• Gabapentin or pregabalin (for nerve hypersensitivity after B6 toxicity).
• Quinine alternatives (quinine itself is rarely used now).*
• Low-dose muscle relaxants at bedtime.
These are not for everyone, but you don’t have to suffer night after night.
6. Consider getting an EMG/nerve conduction study.
Since you had real B6 toxicity and ongoing neurological symptoms, testing can help confirm whether the nerves are still irritated and guide treatment.
You are not imagining this, and you're not alone — B6 toxicity can absolutely cause lingering neurological effects that make cramping much worse, even long after you stop it. The good news is that many people do improve over time once levels normalize, but it can be slow and they sometimes need help managing symptoms during recovery.
I really hope you get some relief soon. You’ve been dealing with more than enough.
@tommy901 thank you for taking the time to record all of this relevant and useful information.
It’s 11 months now since I stopped taking the magnesium with 25mg of B6 and my B6 blood levels have dropped from a frightening 1670 back to within normal range (at 60).
I avoid pharmaceutical ‘solutions’ wherever possible as my experience is that they often solve one problem and create another.
Our bodies are amazing if given good food, fresh air and regular exercise.
It was necessary to resume magnesium (with nothing added) to relieve the nighttime cramps. The fact that it predominantly affected my damaged foot and calf makes me suspect inflammation and vascular issues are also contributing factors.
I did notice that low heart rate severely affected leg cramps. Possibly why they are nocturnal as that is when heart rate usually drops. I took medication to slow my heart in preparation for an angiogram and spent most of the night dancing around with severe leg cramps (both legs!). So low blood pressure - caused by low heart rate or dehydration or vasodilation due to use of a muscle relaxant (such as Valium) which I thought would relax cramps but made them worse (which I attribute to their vasodilation effect) - is also a factor.
Exercise is a tricky balance of getting enough movement without creating inflammation.
My ataxia (unsteadiness) has improved but many peripheral neuropathy symptoms persist. Eyesight and slow memory retrieval (once something I could do at lightening speed) is particularly frustrating. I continue to read and research to stimulate neural pathways (and keep myself busy and satisfied that breathing is not a waste of time).
I do feel I am trending in the right direction despite the fact that time itself is a negative factor.
Kind and informative support from people like yourself, and others in this group, have supported and added to my own ideas, observations and solutions.
We are creating our own valuable, wide ranging case study here.
I sincerely thank you for being part of it.
Australian
Age 73
Normal BMI
Healthy resting heart rate
Healthy blood pressure
Average fitness (not an athlete nor gym user)
Lifetime non-smoker