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DiscussionAnyone have severe bone (spine) loss with recurrence of PC?
Prostate Cancer | Last Active: Dec 19, 2025 | Replies (8)Comment receiving replies
Replies to "Had Prolia from start of Lupron. Taking calcium since ending Lupron. DEXA done twice. Before RALP..."
@grandpun, you may wish to check out these related discussions:
- Did androgen deprivation therapy (ADT) cause bone loss for you?https://connect.mayoclinic.org/discussion/adt/
- Osteoporosis and Osteopenia treatment and prostate cancer?https://connect.mayoclinic.org/discussion/osteoporosis-and-osteopenia-treatment/
- Osteopenia Supplements that work? https://connect.mayoclinic.org/discussion/osteopenia-supplements-that-work/
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@grandpun
One of the primary problems that Lupron causes is thinning of The bones. There was a doctor at one of the conferences about nine months ago, that specialize in bone health and said that everybody who is castrate resistant Should be on bone strengtheners. He emphasized that Lupron is really hard on the bones, And those were on it long-term should be on Strengtheners.
I forgot to mention that vitamin D is another one of the important things needed for keeping bones strong. That was another thing. My doctor mentioned I needed to take daily. I’m sure you’re doing that..
From AI
Lupron can cause bone loss (thinning of the bones) as a side effect, particularly with long-term use. This is because it can decrease sex hormones, which are important for bone density. Doctors can mitigate this risk by using "add-back" therapy with a progestin like norethindrone acetate, ensuring adequate calcium and vitamin D intake, and monitoring bone mineral density with DEXA scans.