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Recovery of testosterone and side effects after stopping ORGOVYX
Prostate Cancer | Last Active: Dec 7 11:00am | Replies (31)Comment receiving replies
@chippydoo
Lupron does not hang around as long as you’ve been on it. The half life of Lupron is 3 to 4 hours. You can get a one month three month four month or six month shot. It will be active as long as the shot is listed for. It doesn’t hang around much longer once the time on the shot runs out it doesn’t stay in the system much longer.
As an example, when I was getting the six month shot, I got my shot three weeks late one time and my PSA went from undetectable to .6 in three weeks. I just happen to get a PSA test right before getting the shot. It went back down to undetectable the next month.
It does take longer for testosterone to come back if you’ve been on Lupron compared to Orgovyx.
I was on Lupron for six years and Orgovyx for nine months. I stopped taking Orgovyx, since my oncologist and I were both sure my testosterone would not come back. In seven months, my testosterone hit 50 and was going up 25% a month. I had to go back on Orgovyx.
Replies to "@chippydoo Lupron does not hang around as long as you’ve been on it. The half life..."
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@jeffmarc
As I understand it, the low testosterone causes the side effects and not the Lupron. This raises the issue of why doctors keep giving Lupron or other ADT to men who have already been chemically castrated by the ADT. Studies show that more than 50% of men will never recover their testosterone levels once treated, yet many men take ADT for many years. My side effects seemed life threatening to me and I had testosterone levels around 200 before treatment. Now 5 months after stopping Lupron I still have serious side effects. Some are getting better while some are getting worse. My PSA is < 0.1 and testosterone < 9 after 5 months.