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Recovery of testosterone and side effects after stopping ORGOVYX
Prostate Cancer | Last Active: Dec 7, 2025 | Replies (31)Comment receiving replies
@pesquallie Lupron is the gift that keeps on giving. I did Lupron for 3 months and went anemic which is tough for someone that is active. I switched to Orgoyx for the second 3 months and felt a lot better and anemia corrected itself. 2 months post treatment psa was undetectable and my T was 210. It is my understanding that Orgovyx has a half life of 25 hours and for us "short termers", Lupron hangs on roughly the amount of time we treated with it. My results were consistent with that.
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@chippydoo
Lupron does not hang around as long as you’ve been on it. The half life of Lupron is 3 to 4 hours. You can get a one month three month four month or six month shot. It will be active as long as the shot is listed for. It doesn’t hang around much longer once the time on the shot runs out it doesn’t stay in the system much longer.
As an example, when I was getting the six month shot, I got my shot three weeks late one time and my PSA went from undetectable to .6 in three weeks. I just happen to get a PSA test right before getting the shot. It went back down to undetectable the next month.
It does take longer for testosterone to come back if you’ve been on Lupron compared to Orgovyx.
I was on Lupron for six years and Orgovyx for nine months. I stopped taking Orgovyx, since my oncologist and I were both sure my testosterone would not come back. In seven months, my testosterone hit 50 and was going up 25% a month. I had to go back on Orgovyx.