Connect
← Return to Does anyone have neuropathy related to MGUS?
Discussion
Does anyone have neuropathy related to MGUS?
Blood Cancers & Disorders | Last Active: 4 days ago | Replies (135)Comment receiving replies
@tracypage hi Tracy. It’s so weird how different drugs impact people differently. I suppose it’s because our blood chemistry and everything else is unique. I was prescribed duloxetine (cymbalta) and didn’t like it at all. It made me feel somehow outside of myself. I was a clinical social worker who worked in mental health and in one form or another for many years. I feel like I owe an apology to everyone who was prescribed psychiatric medications and stop taking them because they made them feel funny. We sort of rolled our eyes, but the truth is out there.
I’m now taking pregabalin and although it does not eliminate all the pain, it helps tremendously. It definitely abates that sharp, unexpected and unexplained pain that I get in my feet and toes in particular. That was brutal.
I had to work with my neurologist to come up with a solution that was right for me, but I am giggling a little because he told me that when I got off the Cymbalta, I would gain weight.
Go figure.
I’d be curious as to how this works out for you if you’d let me know?
Replies to "@tracypage hi Tracy. It’s so weird how different drugs impact people differently. I suppose it’s because..."
Connect
@pmm Thank you! I tried pregabalin a few years ago before this is where it is now, but gained 7 pounds in 7 days and they quickly pulled me off it. My doc says it is really rare for the weight gain while using cymbalta but it is out there. We know Lyrica is out from the past experience. He has sent me a low dose of gabapentin just to see how react but I am trying to not take it until I am off Cymbalta. Gabapentin is a pregabalin too though so neither he nor I are hopeful.
I had been on tricyclic antidepressants when I was having internal shingles maybe a decade ago and my experience was like yours— I could not function and I was drowsy all the time. So I understand what you are saying. I didn’t notice that with cymbalta but I think you are correct, we are messing with blood chemistry and everyone is different.
Our latest idea is they have me on zepbound to help get this 40 pounds back off. I lost 10 just coming off the cymbalta, 30 more to go. And then maybe try combining a low dose of cymbalta with the zepbound. Cymbalta really was the most thorough relief I have had but while my weight went up, my A1C went to 5.9 and my triglycerides soared. My GP is afraid I will end up diabetic if I keep gaining like that.