I suffer from medication allergies (histamine reactions) and I experience severe itching on palms, lower arms and feet nearly every day at around 8 PM. There are sometimes red dots but most times no rash. I keep it under control with a large dose of antihistamine and if uncontrollable, a very small does of prednisone. This is what has worked for me. Speak to your doctor about your situation and severity. I need to note that my allergies are for drugs that keep me alive so for me this is a situation that I must deal with.