← Return to Rising PSA post Prostatectomy. Please, what should I expect or do?

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Profile picture for beachflyer @beachflyer

Hello COA44

The use of active surveillance (AS) following BCR after prostectomy is an option that may be offered based on PSA doubling time and other criteria including post surgical pathology. The argument for AS versus salvage radiation is based on a growing body of evidence that suggests 33 to 50% of men with BCR following prostectomy are over treated as their recurring cancer was indolent or of low grade such that it would not have impacted their life negatively. The issue as you might expect is how to determine which of us have an indolent BCR based on the testing available.
It appears that you have been on AS for a couple years now post prostectomy. Did your doctor discuss the AS criteria with you ? It looks like you had one year of fairly stable PSA around .2 however it is now rising so definitely time to ask questions about treatment options. What was your PSA and post surgical Gleason score and decipher score? That would likely have been a part of any AS plan.

I bring this up as my surgeon is a big proponent of AS following surgery and BCR for some men with favorable pathology. This very topic came up last month on my one year prostectomy anniversary Telemed conference call. I asked my Surgeon what happens if I get a rise in PSA? He said based on the rate of rise and other factors he might likely recommend AS.
BTW , When I chose Dr Ahlering as my surgeon I had to agree to be part of his longitudinal study cohort. He is following UCI PCa patients for the next 15 years tracking their progress and one area of focus is exactly this topic of AS following RARP with a BCR.
Until stepping down last year to focus on research, Dr Ahlering was the Vice Chair of Urology at UCI which is a center of excellence.

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Replies to "Hello COA44 The use of active surveillance (AS) following BCR after prostectomy is an option that..."

@beachflyer excellent point regarding BCR. The rate of rise is SUPER important!
Mine took 5 yrs to get to 0.18 - but over the final year of that interval it really zoomed, which prompted me to have SRT.
Phil

@beachflyer

Thank you so much for your support. It is very helpful.

Over the past six months, I have made two office visits to my Urologist. Each time, he discussed all the treatment options including AS. The Urologist always referenced my Post Surgical Gleason Score, PSA, etc. On the most recent visit on November 6, my wife and I agreed with the Urologist to settle on what/which treatment options during my upcoming office appointment which will be in the first week of January 2026.

I will keep MCC posted on developments after my January 2026 office visit.
Indeed, I am blessed to belong to MCC.

Thank you to everyone for the warm support.