So sorry you are having so much trouble with methroxate. I have been taking it for about 7 months. Side effects for me just ladtbon the day I take it. Mayo has me take 6 pills once a week. On the day I take it, I am very tired and somewhat nauseated. Usually, I take it easy that day and by the next day, I am fine. Perhaps you need a dosage adjustment or some other adjustment. I am no doctor and because I take the drug for a non-painful condition the only way I know it helps is from PET scans and/or CT scans. Good luck to you. Have a conversation with your doctor about your difficulties.

i take the methatrexate injections weekly and it agrees with me. maybe you can try it this way. no nausea or reactions for seven years.

I was diagnosed with RA in 2003 and was given Methotrexate- I took the medication once a week for about 9 years (off and on). I experienced nausea, no appetite, headache and light sensitivity for about 24- hours after taking the medication (also my mood was very sad- maybe from the side effects). My Rheumatologist had me tried different medications throughout the years but they did not helped with the pain, stiffness and fatigue. I was prescribed Xeljanz 10mg in 2014 (I was and still am scared about the long term side effects but it does help me and I only take 5mg daily- I have no side effects from it. I do still get flares, joint stiffness, pain, swelling- but much tolerable. On my last appointment he said he may increase it to 10mg if my flares were not under good control. The long term side effects from this medicine do scare me (that's why I only take 5mg). I have an appt in 2 week- I hope my inflammatory markers are ok. As far as Methotrexate I really don't think it helped with my RA symptoms and having the side effects every week was not a good thing.

I tried methotrexate but the side effects of headache and diarrhea. I also tried suldasalazate but the has only worked for 4 months. Sulfasalazine gas worked up until this year. I am in need of a new drug and tips etc.