Im so happy to hear youll be going to Mayo in May. I understand having to stop medications, sometimes the side effects are too much. I had tried otezla for my skin last year , it made all my tendons hurt. The methotrexate ive been on for 17 yrs, for me its the sweating, yuck. Hoping youll find what works soon. Julie

I used Methotrexate for about a month, several years ago. I was not able to take any of the new biological wonder drugs that are constantly advertised on tv as I have had several cancers. The methotrexate did nothing for my RA, however it damaged my lungs. I now have mild COPD.
Please be careful with this drug, it has many bad side effects.
The RA has ruined my hands/fingers, and is now affecting my toes. Many of my finger joints are fused and can not bend. When this first started, the pain was similar to having knives stuck in my fingers, but that has subsided to a mild pain. I have 3 fingers that are flexible and almost normal. My hands looks terrible, all bent & in winter are purple.

Doctor keeps encouraging me to try Methotrexate and I keep resisting. I would like some anecdotal reports from users who have taken it with success and those who experienced side effects that precluded it. I can read the side effects but would rather hear first hand accounts. I am continuing on medrol and have been for 10 years and all my blood work that methotrexate could affect is now normal. Thank you. M.E.