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Does anyone have neuropathy related to MGUS?
Blood Cancers & Disorders | Last Active: 4 days ago | Replies (135)Comment receiving replies
Has anyone been diagnosed with MGUS (monoclonal gammopathy of undetermined significance) and developed neuropathy? My doctors feel my neuropathy is a result of the abnormal protein from MGUS in my blood. Excruciating pain in my foot and blasts of shocking nerve pain. My dr just started me on 2 weeks of high dose prednisone. I’m told if this doesn’t work there is some type of infusion that may help reverse it. Just curious about other experiences regarding this
Replies to "Has anyone been diagnosed with MGUS (monoclonal gammopathy of undetermined significance) and developed neuropathy? My doctors..."
@positivethinking
I have SMM and yes, there is a correlation between MGUS/smm/mm and neuropathy. These things also can cause low rbcs and iron deficiency and/or anemia. My leg pain was reduced substantially after two iron infusions. Good luck. I know how awful it is.
@positivethinking I have had peripheral neuropathy since a year before they diagnosed me with MGUS. It seems, from what I have read, that people with high Lambda (λ) type: A patient's M-protein may have lambda light chains. A low FLC kappa-lambda ratio generally indicates an overproduction of lambda chains.
It is under control only by my making significant changes to my diet, exercise, stress levels, and home treatment programs. It is now about 60-70 percent better symptom-wise after a year of modifying my diet, exercising, stress management, and taking specific supplements like Alpha Lipoic Acid, PEA, Omega-3 Fish oil, etc.
@positivethinking Yes. I was first diagnosed with neuropathy, then MGUS and now Waldenstrom macroglobulinemia, say that three times. Whew.
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@positivethinking, I combined your discussion with an existing discussion titled:
"Does anyone have neuropathy related to MGUS?"
- https://connect.mayoclinic.org/discussion/mgus-neuropathy/
The discussion has many posts about MGUS and neuropathy. I'd like to introduce you to @canderson12, @kayabbott and @mguspixi25 who have shared their story and how they have tried to manage their diagnoses.