Hi @pza - welcome to Mayo Clinic Connect. Glad to hear you got a diagnosis at Mayo Clinic in 2008 so you know you are dealing with IBS due to non-typical acid reflux. Nice that you've been fine till a year ago with diet and meds, too.

Since you are now having acid reflux during the nighttime, I moved your post here to this existing discussion so you can connect with others with similar experiences:

- Managing nighttime acid reflux https://connect.mayoclinic.org/discussion/suggestion-fudiplication-new-medical-intervention-first-question

Hoping that other members here can make suggestions on what may have helped them or a loved one with bringing up mucus in the middle of the night and feeling acid. Please meet @ripley @bebold @shooei @dancing1 and others in this discussion.

pza - Of the head elevation, famotidine (Pepcid), aluminum hydroxide and magnesium carbonate (Gaviscon) you've tried, did you get any relief at night from your symptoms? Have you had a chance to try the polyethylene glycol 3350 - PEG 3350 (Miralax) 2-3 times per week your doctor suggested?