Exercise as a Prostate Cancer treatment

Here's a webpage with a brief description of how to modify exercise routines so they approximate the eccentric exercise Rob Newton is talking about, that can help facilitate muscle growth in people experiencing almost zero levels of testosterone.

"Pack on muscle with eccentric exercise"
URL: https://www.mensfitness.com/training/how-pack-muscle-eccentric-exercise

This topic is also getting some press. I'm not sure if you guys saw this article in the WSJ (Jun 1 2025).
https://www.wsj.com/health/healthcare/cancer-diagnosis-diet-execise-98386597
or
https://www.wsj.com/health/healthcare/cancer-diagnosis-diet-execise-98386597
In case you can't read it:
"The study spanned more than a decade and is the first to answer conclusively in a controlled trial whether physical activity can improve cancer-related survival, the study’s authors said. Patients in the program had a 37% lower risk of death after eight years, compared with patients who only received educational information on exercise."
Also, The Washington Post (Sep 11 2025) discusses Robert Newton's work, among others:
https://wapo.st/3M6Rm3y
or
https://www.washingtonpost.com/wellness/2025/09/11/exercise-cancer-benefits-prevention-recurrence/

….hot off the press…exciting new research, entitled:

“Running session-conditioned human serum lowers prostate cancer cell spheroid formation”

From the research paper;

“To our knowledge, this is the first study to assess the impact of exercise-conditioned sera on spheroid volume.

These findings provide novel insights into the potential anti-tumorigenic impact of running.

Spheroid volume is a recognized indicator of cell proliferation, viability, and aggressiveness, within a three-dimensional microenvironment that closely resembles the in vivo tumor architecture.

Therefore, volume reduction may mirror a decrease in cancer cell growth “

A summary article can be found here:
https://bioengineer.org/exercise-conditioned-serum-inhibits-prostate-cancer-growth/
For purists, you can find the research paper here:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12535562/
…I figured the research would eventually catch up with me….pardon the pun… 😉

@handera Thank you! Very interesting and encouraging. I had a hard time fully understanding the article so I plugged it into chatGPT and asked it to dumb it down for me. Here’s what it said:

Here’s a plain-language summary of the article “Exercise-Conditioned Serum Inhibits Prostate Cancer Growth.”

✅ What the study did
Researchers collected blood serum from people after they had done running sessions (“exercise-conditioned serum”).

They then exposed prostate cancer cells in the lab to this post-exercise serum, and compared how the cancer cells behaved versus serum from people who had not just exercised.

They looked at “spheroid formation” — a process by which cancer cells group up in 3D clumps, a behavior that often relates to cancer aggressiveness and potential for metastasis (spreading).

🔬 What they found
The exercise-conditioned serum reduced the ability of prostate cancer cells to form spheroids — meaning the cells were less likely to behave like aggressive or metastatic cancer.

The researchers detected changes in certain metabolites and growth factors in the serum after running; these biochemical shifts are believed to be at least part of what caused the anti-cancer effect.

🧑‍⚕️ Why it matters
The findings add to growing evidence that exercise — even just a running session — can influence the body’s biochemistry in ways that may help fight cancer (or at least slow its growth).

It suggests a possible “non-invasive,” lifestyle-based approach to complement existing cancer treatments — not replacing them, but perhaps helping them.

More broadly, the study helps explain one biological mechanism that might underlie why people who are more physically active tend to have lower cancer risk.

⚠️ What this doesn’t mean (yet)
This study was done in the lab with cancer cells exposed to human serum — not directly in patients.

We don’t yet know exactly which molecules in the serum cause the effect — just that some growth factors/metabolites change after exercise and seem involved.

Because lab conditions differ from a real human body, it’s too early to conclude that running (or other exercise) will by itself “treat” or “prevent” prostate cancer.

🧠 Bigger picture
This new research supports a broader scientific trend: many studies have shown that exercise-conditioned human serum (from people after exercise) reduces proliferation (growth), viability, or survival of various cancer cells (prostate, breast, lung, colon) in lab settings.

Because of that, scientists are increasingly thinking of regular exercise as a potential complementary strategy — not just for general health, but as part of cancer prevention or therapy.

@shmo

Thanks for the AI summary, especially the clear definition of “spheroid formation”…a way of quantifying cancer aggressiveness and its potential for metastasis.

The research indicating “exercise fights cancer” has been growing rapidly in recent years and IMO the evidence of its efficacy is very close to reaching “critical mass”.

I would not be surprised to see it incorporated into a future NCCN prostate cancer treatment guideline, coupling it with existing SOC treatment protocols.

As far as I know, exercise is not included in the 2025 NCCN guidelines (someone please correct me if I’m wrong).

So if you’re a strict NCCN SOC PCa man you’ll have to wait….otherwise consider taking a walk (preferably brisk) on the wild side 😉

Standard disclaimer - I am not a physician and I am not providing medical advice….I figure if AI summaries can say… “what this doesn’t mean (yet)”…I should do likewise. 😊

Rob Newton's book is now available on Amazon as a Kindle edition. Search for
"MyExerciseMedicine for Cancer"

@jeffmarc

I do not get tired either and the hot flashes are mild compared to the toe to top of head constant sweating. I have to sleep with no covers, or I get wet at night. My evaporative cooling system is on full blast 24/7 which leaves me quite cold all day long.

@surftohealth88
Here’s a Picture of the bottle

@jeffmarc

Aaawe Jeff you remembered !!! < 3 : )))
THANKS !!!!
And you said that you have "fuzzy brain" due to meds - I think NOT ! ha ha

I will look it up : )) and thanks again, it is very much appreciated < 3

Well, what we know...

Exercise can have benefits...

I exercise pretty much every day, either at the gym (279 days), indoor bike, weights, swimming, or outside, riding my bike 25-25 miles. I do my own yard week, help out withe household chores, walk my dog...our vacations are pretty active, involving a lot of hiking or skiing.

My weight is under control as is my blood pressure, not diabetic...

I talked with my cardio vascular team this week, routine six-month check in. I was talking that since 2010 when I turned 54 I had experienced:

DVT
PE
PCa
Afib
TIAs

Anyone could have ended things..why didn't one? We surmised that my diet and exercise better enable my body to counter these events. Makes sense, though I can't support with any "scientific" data.

We "know, " or at least intuitively understand that diet and exercise can play a role in mitigating some of ADT's side effects.

Attached is one article I found that discusses the role of exercise in fighting PCa, notice I didn't say in preventing...the basic theory as I read it is exercise strengthen one's immune system, thus when you knock the PCa down, the immune system is in better position to attack the remnants.

Don't mind me, layman, study of one...

Kevin