Connect
← Return to Brinsupri follow-up
Discussion
Comment receiving replies
@winterfelllvoyager75 I would love to hear the explanation at our Brinsupri works
Replies to "@winterfelllvoyager75 I would love to hear the explanation at our Brinsupri works"
@sharonednaramsey This is from Google AI Gemini. I hope this helps. There is also information on the NIH PUBMED.
The benefits of Brinsupri, a prescription medicine used to treat non-cystic fibrosis bronchiectasis (NCFB) in adults and children 12 years of age and older, as indicated by clinical studies, include:
* **Reduction in Flare-ups (Exacerbations):** Studies showed that patients taking Brinsupri experienced a reduction in the annual rate of pulmonary exacerbations compared to placebo, by around 19.4% to 21.1% depending on the dose.
* **Delayed Time to First Exacerbation:** The medication helped prolong the time until the first pulmonary exacerbation occurred.
* **Increased Exacerbation-Free Period:** It increased the proportion of patients who remained exacerbation-free over the treatment period.
* **Slower Decline in Lung Function:** The 25 mg dose, in particular, was shown to reduce the decline in lung function, as measured by forced expiratory volume in one second ($FEV_1$), compared with placebo.
* **Improved Quality of Life:** Patient-reported outcomes related to respiratory symptoms also improved with both treatment doses.
* **Targeted Mechanism:** Brinsupri is a first-in-class DPP1 inhibitor that targets the underlying cause of inflammation in NCFB, by blocking the activation of neutrophil serine proteases which are key drivers of chronic airway inflammation.
The web page context also mentions a patient's personal experience that Brinsupri is a medication that takes **3-6 months to experience its full benefits**.
Would you like more information about how Brinsupri works?
Connect
@sharonednaramsey My understanding, simplistically.
We with bronchiectasis have overactive enzymes called DPP1 (neutrophil related which is a type of white blood cell). These enzymes make airway inflammation worse causing more mucus, leading to more infections, and more lung damage. Brinsupri blocks DPP1. As a result, the airways are less inflamed, and less prone to flares. With hope and time, we experience less inflammation, fewer exacerbations, better lung function.