@sjs1 I started on areds 2 nearly 10 years ago AMD diagnosis. I had no side effects and there seemed to be no noticeable progression of AMD. However 5 + years ago I was fortunate to get a kidney transplant after a 5 year wait on dialysis. The transplant team examined the supplements I took and there was no recommendation for change. However as I was doing research on the web concerning areds 2 I came across 3 interesting issues concerning its high level of zinc. 1. That taking areds 2 for a long period of time that even though it contains high copper additive , copper deficiency can occur. 2. That a areds 2 without zinc supplement maybe just as effective. 3. That through my experience can be highly deferments to yout health because zinc can drop suddenly and does not always return to normal levels while leaving copper levels also low. So invariably continued supplementation is needed. These low levels can play havoc with many systems in your body as well as the adrenal system and possibly result with tumors which my medical team is evaluating. Since I take tacrolimus for my transplant and zinc has tendency to alter the efficiency of that drug there is also concern as to how any change in zinc supplementation will affect that treatment. So again emphasize the need for expansion of caution labeling on the product. This product has definitely shortened my life span.