We took one single-overnight trip to Phoenix (just a hour and a half from home, where we’ve gone a jillion times) late in the spring that was quite difficult. Spouse was continually confused, could not keep track of his personal items (though they were right there), etc.
Then in late July we took a 6-day road trip with one of my sons that was fantastic. This involved air travel and then daily driving and a new hotel room every night, all to places unfamiliar to him.
For both “adventures” I did extra contingency planning and don’t know why the outcomes were so different.
I traveled for a few days once without him since his diagnosis. I spent a couple weeks lining up all kinds of help at home during my absence and he did fine. I think I prefer that scenario to traveling with him at this point. Makes me sad though.