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ADT, Hot Flashes and Ashwagandha: Is it safe?
Prostate Cancer | Last Active: Nov 25, 2025 | Replies (23)Comment receiving replies
The Lupron level was obviously way too high for me and was becoming life threatening. I had no choice but to stop treatment. I find it hard to believe that everyone absorbs Lupron at the same rate. More than 7 months after my 3-month shot I still have essentially the same testosterone level and side effects are still severe but not quite as bad as 3 months ago. It seems I am still processing the Lupron when it should have been gone. I am more than a month beyond the normal half-life.
Replies to "@jeffmarc The Lupron level was obviously way too high for me and was becoming life threatening...."
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@pesquallie
Lupron is pretty perfected in how it works. I remember when my father told me it stopped working and it was the only drug I had available at the time. While Lupron may have left your system, testosterone doesn’t come back the same for everyone.
You are not processing Lupron after 3 months because it’s half life is 3 hours, you are processing your low testosterone caused by Lupron.
Some scientific information
The elimination half-life of leuprolide acetate (the active ingredient in Lupron) in the bloodstream is approximately 3 hours.
If you get a three month shot…. medication is embedded in biodegradable microspheres that slowly release the drug into the body over a 12-week (3-month) period. This unique delivery system ensures continuous therapeutic drug concentrations are maintained throughout the entire 3-month dosing interval, effectively extending its duration of action.