Has anyone had success taking Alpha lipoic acid for neuropathy?

Posted by carol1024 @carol1024, Nov 18, 2025

Has anyone had good results taking Alpha lipoic acid for neuropathy caused from Chemo (CIPN)? A fellow patient told me she didn't have neuropathy anymore and when I asked why, she said she was taking Alpha lipoic acid. I bought some and after getting approval from my oncologist, started taking 2 a day, the recommended dosage. When I did research to validate the benefits, some info was positive while some was indifferent. I honestly think it's working. It's been about 2 weeks. I will suggest if you do start using it, take it with a soda. I tried water, milk, after a meal and I had heartburn so bad. When I decided to take it with soda I had no heartburn at all. Dr Pepper works for me and I take it on an
empty stomach with my regular morning meds. I was just curious if someone had any positive feedback. Thanks

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Profile picture for bingo2a @bingo2a

It has not helped me. I’ve been taking it for about a year now.

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@bingo2a are you taking the R or the S? You could try it with this cream I found while searching capsaicin cream that's supposed to be good for neuropathy. I LOVE this stuff. Only been using it for about 3 says and once a day. I wanted to go slow to see if I had any reaction to it. So far so good. It says to apply as often as desired.

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Profile picture for bingo2a @bingo2a

@janekwick
I take 600 mg of alpha lipoic acid daily and 500 mcg of B-12 but no improvement. Can I ask how much alpha lipoic acid you take daily?

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@bingo2a 600mg twice a day ALA and I take 2 B complex plus a multivitamin. Thinking about asking doctor about B 12 shots once a month. Won't hurt to ask. Either that or I'll get pure B 12 to take. I just ordered the R ALA and I'll see if that makes a difference.

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Two years ago, I started taking ALA 600 mg once a day, no help. Switched over to R-ALA 600 mg daily, did not notice any difference. In January of this year, with doc approval, went to 1200 mg R-ALA daily, one in morning and one in evening. I'm sure there is noticeable improvement, but I am not sure if progression has decreased. The jury is still out but for now, I will continue taking 1200 mg. daily. Ed

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Profile picture for carol1024 @carol1024

@bingo2a 600mg twice a day ALA and I take 2 B complex plus a multivitamin. Thinking about asking doctor about B 12 shots once a month. Won't hurt to ask. Either that or I'll get pure B 12 to take. I just ordered the R ALA and I'll see if that makes a difference.

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@carol1024
This is the first I am hearing about R ALA. I will ask my doctor about it and the B vitamins and multi-vitamin.

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Profile picture for carol1024 @carol1024

@bingo2a are you taking the R or the S? You could try it with this cream I found while searching capsaicin cream that's supposed to be good for neuropathy. I LOVE this stuff. Only been using it for about 3 says and once a day. I wanted to go slow to see if I had any reaction to it. So far so good. It says to apply as often as desired.

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@carol1024 thank you. I will definitely look into this cream also since I am not using any creams at this time.

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Profile picture for bingo2a @bingo2a

@carol1024
This is the first I am hearing about R ALA. I will ask my doctor about it and the B vitamins and multi-vitamin.

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@bingo2a R-ALA is produced naturally by the body. The ALA-S is synthetic. If a bottle doesn't have any type on it, like mine did not, it is 50/50 of R and S. I've just read that the R is better.

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Profile picture for darinjasman @darinjasman

@carol1024 if nerves are totally dead then how are you able to feel sensation still? Just curious.

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@darinjasman they aren't totally dead. They're like your foot or hand feels just as the feeling is starting to come back in it.

I owned a hair salon for over 20 years. I have a pinched nerve in my neck in back. My shoulder on left would get numb all the way to just past center of neck. The pain was awful.

I could scratch it and feel absolutely nothing. The feeling came back only after I lay on bed. That went on for YEARS. I have feeling in the are very good now.

So I guess if it's just numb temporarily even though for a long time and you release that nerve being pinched then it doesn't die.

I've not had any nerves that got 100% numb permanently.

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Profile picture for NJ Ed @njed

Two years ago, I started taking ALA 600 mg once a day, no help. Switched over to R-ALA 600 mg daily, did not notice any difference. In January of this year, with doc approval, went to 1200 mg R-ALA daily, one in morning and one in evening. I'm sure there is noticeable improvement, but I am not sure if progression has decreased. The jury is still out but for now, I will continue taking 1200 mg. daily. Ed

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@njed I take 600mg but take twice a day. Could be that and the cream I ordered. I am having amazing results with that. I'm getting treatment now and have given info to several people. One is too big but you can Google Dermavitality and get all info. It's for oncology patients.

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Profile picture for carol1024 @carol1024

@bingo2a R-ALA is produced naturally by the body. The ALA-S is synthetic. If a bottle doesn't have any type on it, like mine did not, it is 50/50 of R and S. I've just read that the R is better.

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@carol1024 I read the same as you, that R is better. Going to ask my doctor about it.

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My neurologist put me on it and I do think it has helped.

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