@clowny I was very lucky to have a good experience with my Reclast infusion. But I followed advice on here and from my doctor to the letter...start hydrating extremely well two days before, the day of, and two days after. Take Tylenol and an antihistamine as well. These things all help with what is called an acute phase reaction. Be sure you ask for a 45 minute infusion with a "saline push", I think they call it and a flush afterward. But everyone is different, and other health issues could impact your reaction, I would guess. Good luck to you!