Treatment for CLL: Any experiences with Brukinsa (zanobrutinib)?

Posted by siagolfer @siagolfer, May 21 8:00am

Started therapy for CLL after 2.5 years of wait and watch with my excellent doctor at Mayo and local haematologist.This was predicted based on prognostic factors of age(77 now) IGHV unmutated and size of lymph nodes by CT scan . 5 out of 10.No TP 53 disruption
Until that time many background tests done including FISH, CT CBC weight loss etc
Before starting therapy had CT scan, bone marrow sampling,skin check, EKG etc
Doctor gave me a choice of Brukinsa( Zanobrutinib) or combination of Venetoclax plus obinutuzumab both being equally effective in my case.l chose the capsule therapy vs Infusions for convenience.
The doctor stated me at the half dose of Zanobrutinib ( Brukinsa ) 80 mg twice a day two weeks ago.
So far no side effects. Taking allopurinol and acyclovir also.
In two weeks my WBC has gone up from about 90 to 150 and platelets down from 100 to 80.This is as per expectation since the cells from my nodes are now in my blood stream and BTKi impacts bone marrow (platelets)
Sizes of my nodes has shrunk significantly
Uric acid on target.
I have to watch out for bruising or bleeding.
So far so good.No changes in diet or lifestyle.
Name of game is stay positive!

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clutch | @clutch | Oct 6 1:40pm

In reply to @bochos "@clutch After getting two infusions of blood and 4 infusions of Ribitoux things are back to..." + (show)

@bochos
I was actually asking about "wait and watch" in early stages. Do most oncologist agree on this practice?

tezy15plus5 | @tezy15plus5 | Nov 9 7:36am

I've been prescribed Brukinsa 80mg (zanubrutinib) 4 capsules daily plus Allopurinol tablets 300mg 1 daily plus Co-Trimoxazole 160mg/800mg 1 tablet twice a day on Mondays and Thursdays only. Does anyone know of the side effects I might have while taking this medication please.

siagolfer | @siagolfer | Nov 9 10:20pm

In reply to @tezy15plus5 "I've been prescribed Brukinsa 80mg (zanubrutinib) 4 capsules daily plus Allopurinol tablets 300mg 1 daily plus..." + (show)

I have been on Brukinsa 80X2 per day( half dose due to age 77) and two tabs acyclovir as per advice from m Mayo haematologist
I was on allopurinol for the first three months but stopped once my lymph nodes got significantly less and chance of TLS reduced

So far no major side effects except earlier some bruising
Blood CBC near normal.

siagolfer | @siagolfer | Nov 9 10:20pm

In reply to @siagolfer "I have been on Brukinsa 80X2 per day( half dose due to age 77) and two..." + (show)

@siagolfer
Six months on treatment

Colleen Young, Connect Director | @colleenyoung | 1 hour ago

In reply to @tezy15plus5 "I've been prescribed Brukinsa 80mg (zanubrutinib) 4 capsules daily plus Allopurinol tablets 300mg 1 daily plus..." + (show)

@tezy15plus5, I moved your question about side effects to this related discussion:
- Treatment for CLL: Any experiences with Brukinsa (zanobrutinib)?https://connect.mayoclinic.org/discussion/cll-zanobrutinib/

How are you doing with Brukinsa? Any side effects? How long have you been taking it?

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