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Switching from alendronate to something else
My primary care is referring me to an endocrinologist. I’ve been on alendronate for 5 years and it’s time to change. My lumbar spine T score is -2.6. My hip is -2.1. I’m on Medicare with a supplement and need to select a part D plan that will cover whatever drug the endocrinologist recommends. Hopefully I know before December 7th open enrollment deadline. What do you think my medication options are? I’m 67, taking calcium plus vitamin D and lift weights 3x’s/week. No fractures but sore lower back and left hip.
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Has anyone heard of or tried NAD+which is suppose to “wake up” osteoblasts? Just reading about a product called Thryve NAD+(brand name) to be taken with calcium and D in place of Fosomax. Thanks for any feedback.
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1 Reaction@sharonkay I too have been reading about NAD+, and looking for the science behind the recommendations.
What did I learn?
Mayo Clinic has looked at NAD supplementation, and has cautions about using it:
https://www.nad.com/news/nad-precursor-nrh-inflammation-macrophage-immune-cells
Most of the studies reporting increased osteoblasts so far were performed on mice. Have you seen any independent studies involving humans?
There is a very interesting article about how much NAD+ is enough, and whether it should be taken routinely as a supplement, since we don't yet know the full long-term effects of using it. Here is a chart from the the article Oxford Journal that outlines the gaps in our knowledge:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10692436/figure/F5/
Finally, I think the label on Thryve NAD+ label, on their own website, says it all: "RESEARCH USE ONLY NOT FOR HUMAN CONSUMPTION"
Remember, these supplements are neither regulated nor tested by the FDA.
@sueinmn Thanks so much for your reply. I have not done any in depth research so I appreciate your info and I’ll check out the links